Methyl 1-Boc-pyrrolidine-...
Methyl 1-Boc-3-pyrrolidinecarboxylate
CAS: 122684-33-7
Molecular Formula: C11H19NO4
Methyl 1-Boc-pyrrolidine-... - Names and Identifiers
Methyl 1-Boc-pyrrolidine-... - Physico-chemical Properties
| Molecular Formula | C11H19NO4 |
| Molar Mass | 229.27 |
| Density | 1.120±0.06 g/cm3(Predicted) |
| Boling Point | 105℃/0.2mm |
| Flash Point | 128.32°C |
| Vapor Presure | 0.002mmHg at 25°C |
| pKa | -2.65±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.4560 to 1.4600 |
Methyl 1-Boc-pyrrolidine-... - Reference Information
| introduction | 1-Boc-pyrrolidine -3-methyl formate is a yellow or yellow-brown low melting point solid at normal temperature and pressure, which is an amino acid derivative and can be used to prepare biological enzymes, hormones and some vitamins. |
| use | 1-Boc-pyrrolidine -3-methyl formate can be used as a biological hormone and pharmaceutical intermediate. In the synthetic transformation, the ester can be easily reduced to aldehyde or hydroxyl groups, and the Boc group in the structure can be easily removed under acidic conditions to obtain secondary amine products. |
| synthesis method | 1-benzylpyrrolidine -3-carboxylic acid methyl ester (1.13g) is dissolved in ethyl acetate (100 mL), palladium carbon (10%, 385 mg) is added to the solution, and then ditert-butyl dicarbonate (1.35g, 6.18 mmol, 1.2 equivalent), hydrogenated at room temperature for 8 hours, filtered the suspension through diatomite, and concentrated the filtrate under vacuum. The residue (75:25, hexane-ethyl acetate) was purified by silica gel rapid chromatography. Synthetic route of Fig 1-Boc-pyrrolidine-3-methyl formate |
Last Update：2024-04-09 20:52:54
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